FAQ
What is Lëtz Go Gold
LËTZ GO GOLD is a charity run organized by the Fondatioun Kriibskrank Kanner and takes place on Saturday morning, September 23, 2023. Each participant agrees to collect a minimum of €200 (€100 for minors and students under 25 years of age) to fund paediatric cancer research: find new cures, improve existing ones, and learn more about the causes of paediatric cancers.
100% of the donations collected will be allocated to research projects selected by Fight Kids Cancer thanks to the sponsoring partners who cover the costs of the event.
Who can register?
Anyone who agrees and commits to collect the defined minimum amount of € 200 and who wants to run or walk 5 or 10 km on Saturday 23 September in Luxemburg. The 1.5 km circuit is accessible to strollers and all terrain wheelchairs.
Can minors sign up?
Yes minors can register, but must have a parental consent form, completed by a parent, and present it on the day of the event. Children under 12 must be under the supervision of an adult during the run.
Is registration for the race free?
No, the registration costs are €10.
In exchange, you will receive:
- The official running t-shirt of the LËTZ GO GOLD charity run
- Water supplies and snacks during the run
- A Poldi bag with a few of surprises
Overall, your registration in the LËTZ GO GOLD charity run allows you to take part in an unforgettable party!
Is the LËTZ GO GOLD charity run timed?
No, the participant's time is not recorded. Participants who would like to know their time will have to record it themselves.
The podium celebration will reward those participants who have collected the most – individually and as a team.
Can I volunteer (instead of running or walking)?
To make the LETZ GO GOLD charity run a successful event, we need a large number of volunteers. To apply, you must be 18 years old or older on September23, 2023. Send an email to gogold@fondatioun.lu to introduce yourself and explain in a few words why you would like to volunteer.
How can I become a LËTZ GO GOLD partner / sponsor?
For each edition of the LËTZ GO GOLD charity run, we need a certain number of sponsors to cover the costs of the event and thus allow to allocate 100% of all donations collected to the selected paediatric cancer research projects.
If you are interested in sponsoring and require more information on the different partnership packages, do not hesitate to contact us by mail, veerle.dierick@fondatioun.lu or by phone at +352 31 31 70.
What are the rules and regulations of the LËTZ GO GOLD charity run?
Here is a link to the rules and regulations of the run which we recommend you to read.
Registration
What you should know
The registration fees have been lowered to €10 per participant. You must collect €200 (€100 for minors and students under 25) to complete your registration and guarantee your spot at the starting line.
If you are unable to raise this amount, unfortunately, you will not be able to participate in the run. It may sound harsh but we cannot tolerate any exceptions without losing the uniqueness of our charity run concept.
100% of the donations will be allocated to paediatric cancer research projects aimed at discovering new cures, improving existing ones and learning more about the cause of paediatric cancers. All organizational costs of the LËTZ GO GOLD charity run are funded separately by our sponsoring partners.
The registration procedure
1. Getting started
Go to the home page and click on the “register” button.
If you want to run with an existing team (friends, family, private), go to the page of this team, which you will find either through the link sent by the captain of the team, or via the search engine. On the page of this team, register by clicking on the button “Join the team”.
Fill in the registration form and pay the €10 registration fee. You will then receive an email informing you that you are registered and can start collecting funds.
If your company participates in the LËTZ GO GOLD charity run as a team, get in touch with the contact person in your company before creating your own fundraising page. You may have special registration or collection conditions.
2. Create your fundraising page
The information provided in the first step will automatically appear on your fundraising page.
To warm your friends and family, add a nice picture and a personal message to your fundraising page. Explain to them, in a few words, why you are participating in the LËTZ GO GOLD charity run. Why in your opinion it is important to fund paediatric cancer research? We will provide you with a few text samples which you can customize.
3. Broadcast and collect
Each participant must raise a minimum of €200 (€100 for minors and students under the age of 25) through his LËTZ GO GOLD fundraising page.
Talk about the LËTZ GO GOLD charity run around you: friends, neighbours, family, colleagues, school, ... and convince them to support you and share your fundraising page on social media. Feel free to consult the tips and tricks in the FAQ section on how to best fundraise.
Each donation gives right to a tax certificate that will be sent directly by email to the donator as soon as his payment is validated.
If you want to join the LËTZ GO GOLD team in your company, get in touch with the contact person in your company before creating your own fundraising page. You may have special registration or collection conditions. Do not hesitate to ask for our help via gogold@fondatioun.lu.
When is my registration final?
Your registration is considered final once the €200 have been collected (€100 for minors and students under 25 years). Only then will you be allowed to participate in the run. We will send you small reminders as long as you have not reached your goal, and an email confirming your registration when you have reached the minimum amount.
What happens when I collected the defined €200 ?
Congratulations! You will receive an email a few days before the LËTZ GO GOLD D-Day confirming your registration and participation.
What is the deadline to collect the €200 ?
For organizational purposes, all registrations must be made by September 19, 2023 at midnight.
By this date, you must have collected at least €200 (€100 for minors and students under 25) via your LËTZ GO GOLD fundraising page to be able to participate in the run on September 23, 2023.
If you were unable to collect €200 (€100 for minors and students under 25 years old) on September 23, 2023, but you managed to find a few last-minute donators before the start of the run, we kindly ask you to present proof of your additional donations (e.g. by showing your fundraising page on your smartphone or your registration confirmation email).
It is important to know that your entourage can continue to support you after the run as well. You will have access to your fundraising page until October 31st,2023.
What happens if I am unable to collect the €200 ?
If you fail to collect the minimum amount, you will not be able to participate in the run. It may sound harsh but we cannot tolerate any exceptions without losing the uniqueness of the concept of our solidarity run.
100% of collected donations will be used to fund research projects against childhood cancer. So if you have not reached the goal, the amount collected will still be added to the total of the funds collected via the charity run.
You will can more information in the rules and regulations.
Can I cancel my registration and get a refund?
The registration fee is non-refundable.
It is impossible to transfer your registration to a third party.
If you change your mind and do not want to run anymore, 100% of the money you have raised will be used to fund research projects against childhood cancer.
You can find more information in the rules and regulations.
Do I need a medical certificate to participate?
No, you do not need a medical certificate. We let you self-assess your health and assume that if you register, you are able to run or walk in the LËTZ GO GOLD charity run.
Create / join a team
Can I participate with a team?
You can create a team profile with your friends, family, colleagues, class, school, youth movement, etc. This allows you to get together as a team and collect as many funds as possible for research against childhood cancer.
Please note that each participant must always collect a minimum of €200 (€100 for minors and students under 25) to participate in the LËTZ GO GOLD charity run on Saturday morning, September 23, 2023.
The creator of the team is the captain by default and will track everyone's collection efforts. He will encourage everyone to raise the minimum amount and even better, to become the 2023 team that has collected the most funds!
A few days before the closing of the fundraising, the captain of the team will have the opportunity to equally spread the donations to ensure that each member of the team can participate in the LËTZ GO GOLD charity run.
If your team has more than 30 participants with complete registration, your team will be entitled to its own tent in the village on Saturday morning September 23, 2023.
How can I create my own team?
You must start by creating your personal fundraising page. Then you will have the opportunity to create your team.
Personalize your team's page with a motivating picture, tell potential donators who you are and why you choose to participate in the LËTZ GO GOLD charity run and how much you would like to collect as a team.
Those who want to join your team can do this by searching the team via the search engine and clicking on the button "I join this team".
How to promote my team?
Give free rein to your creativity! Run with a hat, a cape, a wig, original makeup, ribbons or banners… just make sure your t-shirt remains clearly visible.
How to join an existing team?
If you want to join an existing team, you must first create your personal fundraising page. Thanks to the search engine, you can then search for a specific team and join it by clicking on the button “I join this team”.
If you want to join the LËTZ GO GOLD team of your company, get in touch with the contact person in your company before creating your own fundraising page. You may have special registration or fund collection conditions.
In case the contact person at your company is not available, send an email to gogold@fondatioun.lu who can help you.
How to create a team for my organization?
Each corporate team will be managed by the Fondatioun Kriibskrank Kanner.
If you wish to constitute a team within your organization, send your request to gogold@fondatioun.lu. If your team reaches or exceeds 30 participants, your team will be entitled to its own tent on September23, 2023. Another advantage: your t-shirts will be waiting for you in your team’s tent. No need to go to the retrieval tent!
Fundraising
How to collect funds effectively – a few tips.
- Choose a nice picture for your fundraising page. This will make it more personal and show your commitment to childhood cancer!
- On your fundraising page, explain why you want to participate in the LËTZ GO GOLD charity run. Talk about your motivation to fund research against childhood cancer. Maybe you know someone who has had cancer as a child, or maybe participating in the run isis important to you just because you think children deserve better cures. We will help you with some sample texts but your own words will always have more impact. You can always edit your text later if you have other ideas.
- If there is little activity or personal content, your environment will probably feel less encouraged to support you and make a donation on your fundraising page. For this reason, we recommend that you first contact your closest friends and family to support you (by sending them a link to your fundraising page). Perhaps you can make the first donation yourself. Good to know: typically, the amount of the first donation sets the tone for the following donations…
- When your fundraising page is starting to take off, talk about the LËTZ GO GOLD charity run around you, to your acquaintances, to your extended family, to your co-workers, to your classmates ... and convince them to support you as well. Now would be a good time to share your fundraising page on social media.
- Are you organising a celebration at your home anytime soon (birthday, barbecue, drink with friends, …)? Ask your guests to make a donation on your LËTZ GO GOLD fundraising page instead of bringing flowers or a gift. This is an excellent opportunity to draw attention to your commitment and increase your donations counter!
- Why not set up a small fundraising business? You can organise a cake sale, make bracelets and sell the products you have made at school, to your neighbors and your family to support research against childhood cancer. Every initiative is a good initiative.
Remember that your registration will be considered final only when you have collected a minimum of € 200 (€ 100 for minors and students under 25). Only then will you be allowed to join the starting line on September 23rd 2023 in Luxemburg.
Do I really have to collect funds?
Yes! Each participant must raise a minimum of € 200 (€ 100 for minors and students under the age of 25) through his LËTZ GO GOLD fundraising page.
Don’t worry, it's a lot easier than it looks! Talk about the LËTZ GO GOLD charity run around you, to your friends, to your colleagues, to your neighbors, to your family, ... and convince them to support you. Don’t forget to share your fundraising page on the social media.
Donations
How can I donate? How do I support a participant?
Go to our home page and click on "donate".
Look for the runner / walker you want to support by entering his name in the search box, select it and once on his fundraising page, click on the “donate” button.
If you cannot find the participant you want to support, ask them to send you the link of their fundraising page.
If you know none of the participants, but you want to support our paediatric cancer research projects, then select the fundraising page of our mascot, Poldi.
Where will my money go?
100% of donations will be allocated to research projects aimed at finding new cures, improving existing ones and learning more about the cause of paediatric cancers.
All organizational costs of the LËTZ GO GOLD charity run are funded separately by our sponsoring partners.
Are donations treated with confidence?
We have chosen a reliable and experienced partner (Raise and Shine) for your donations and the registration of your personal data; all your personal data will be treated with absolute discretion and kept secure at all times.
The total amount of your donation will be transferred directly to a specific account of the Fondatioun Kriibskrank Kanner and will be fully allocated to the research projects against childhood cancer. This is possible thanks to our partners who are financing all costs of the LËTZ GO GOLD charity run.
Will I receive a tax certificate?
Upon validation of your payment, each donator will receive a tax certificate by simple return email.
The Race
Access
We are working hard to ensure that your arrival and access to the LËTZ GO GOLD village is easy. We encourage you to use public transport and carpooling, as the number of parking spaces is limited this year.
Entry of the site
We recommend that you arrive at least one hour before the start time of the event (11:00 a.m.) in order to have enough time to pick up your t-shirt and enjoy the collective warm-up session.
Program
09:00 — Opening of the LËTZ GO GOLD village. Welcome, luggage storage, start of animation in the village
10:30 — Collective warm-up
11:00 — Start of the run
12:15 — Collective cool-down
12:30 — Official ceremony with podium celebration, minute of silence, check handover
13:15 — Closing concert and lunch (food trucks)
14:00 — End of the event
At what time should I arrive?
The LËTZ GO GOLD village opens at 09:00 on Saturday morning 23 September 2023
The run starts at 11:00. We advise you to arrive at least one hour in advance to collect your t-shirt and Poldi bag and to enjoy the collective warm-up session.
What should I bring along?
You must bring the following documents to the retrieval tent:
- the email confirming your definitive registration testifying your fund collection of minimum €200 (paper version or your smartphone) or your identity card
- if you are over 18, and you are still a student: your student card (in case you have collected between €100 and €200),
- if you are under 18 years of age: your signed parental authorization authorizing your participation in the race.
Once this step is completed, you will receive your t-shirt and Poldi bag.
Where will I get my t-shirt?
T-shirts and Poldi bags are to be collected from the booth of the Fondation à la Belle Etoile (route d'Arlon, Bertrange) on September 21 and 22 between 10 a.m. and 5 p.m.) only by participants whose registration is considered as definitive (200€ collected, 100€ for participants under 18 and students under 25).
- Thursday 21st and Friday 22nd of September between 10 am and 7 pm
All other participants can still collect their t-shirt and Poldi bag on the day of the run, with their proof of minimum collection reached.
Please present the following documents:
- the email confirming your definitive registration testifying your fund collection of minimum €200 (paper version or smartphone) or your identity card
- if you are over 18, and you are still a student: your student card (in case you have collected between €100 and €200),
- if you are under 18 years of age: your signed parental authorization authorizing your participation in the run.
Is there storage for sports bags?
Yes, next to the retrieval tent, there will be a tent where you can safely drop off your gym bag. You will receive a ticket and after the run, you can pick up your bag with the ticket. Please put your name and phone number on your gym bag.
Can I change my route before D-Day?
Yes it's possible! Through your user account on online, you can access your options and change your route before the 23 September. If you have trouble to do so, contact us at gogold@fondatioun.lu before the run and specify the route you prefer to follow: 1.5 km walking, 5 km walking or running or 10 km running.
Can I run with a stroller and children?
The 1.5 km course is open to all-terrain strollers and to small children under 12 years old, provided an adult accompanies them.
Can I participate in a wheelchair?
The LËTZ GO GOLD charity run is inclusive and people with reduced mobility or handicap are welcome. We recommend “all terrain” wheelchairs.
Can I bring my pet?
No, pets are not allowed to participate in the LËTZ GO GOLD charity run. The place and the animation on the site – both in the village and throughout the different routes – are not suitable for the needs of our four-legged friends.
Will there be a podium celebration?
Yes, there will be 3 categories: the best individual collector, the best team and the best corporate team.
Will I be filmed or photographed?
Yes, throughout the run and within the village, photographers and a team of videographers will take pictures and film the event.
By registering in the LËTZ GO GOLD charity run, you have accepted the rules and regulations, and therefore the possibility of being filmed and photographed. All photos and videos belong to the Fondatioun Kriibskrank Kanner.
Where can I find pictures and movies after the event?
After the LËTZ GO GOLD charity run, all pictures and films will be available on www.letzgogold.lu.
You can also follow us on YouTube, Facebook, Twitter, Instagram and LinkedIn.
On-site Amenities
Sports bag storage and changing rooms
Next to the retrieval tent, there will be luggage storage where you can drop off your gym bag safely.
There are changing rooms, but no showers on site.
On the course, there are two water and food supply stations available for all participants.
Food trucks
In the LËTZ GO GOLD village, there will be several food trucks selling their culinary specialities (including vegetarian dishes). We would like to thank you in advance for keeping the LËTZ GO GOLD village clean by throwing your garbage in the bins provided.
Partners
GOLD
SILVER
BRONZE
Would you like to become a sponsor of the run, co-finance all organization costs and therefore ensure that 100% of the funds collected by the donors is attributed to selected research programs? Please contact us by email or by phone: veerle.dierick@fondatioun.lu, +352 313170
Financed Projects
In fact, the “Fight Kids Cancer” initiative annually launches an international call for projects aimed at all European researchers working on pediatric cancers. Our common goal is to accelerate the development of more effective treatments to save more lives of children with cancer.
Meeting the strict criteria of innovation, international collaboration and significant impact on young patients, all projects are analyzed and ranked according to criteria of excellence by a panel of independent international experts.
Here are the 9 selected projects. The summary is in French for the moment. Translation is coming.
9 projets innovants pour guérir plus et mieux les cancers pédiatriques
1. PATOI, une nouvelle stratégie thérapeutique prometteuse contre les tumeurs cérébrales
Les tumeurs cérébrales font partie des tumeurs solides les plus courantes et mortelles chez les enfants et les adolescents. Malgré les améliorations apportées par des traitements tels que la chimiothérapie, la chirurgie et la radiothérapie, les perspectives pour les patients vivants avec ces tumeurs à hauts risques sont très sombres. De plus, ces dernières années, peu de progrès ont été réalisés dans le développement de nouveaux médicaments pour les tumeurs cérébrales.
Cet essai clinique vise à tester un type d’inhibiteur (PARPi), développé pour traiter des cancers causés par des mutations spécifiques. En effet, il a été démontré que ce dernier améliore l’espérance de vie des patients vivants avec d’autres formes de cancer, ce qui rend cette stratégie prometteuse pour le traitement de tumeurs cérébrales pédiatriques. Les patients participant à cet essai clinique seront recrutés en Autriche, Allemagne, au Danemark, en Espagne, en France, en Italie, aux Pays-Bas et au Royaume-Uni.
Cette étude s’effectuera au sein de la plateforme « Access Secured – European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors (AcSé-ESMART) ».
Durée du projet : 2 ans
Nombre de patients : 58
Domaine : Essai clinique sur les Tumeurs cérébrales
Institution principale : Institut Gustave Roussy, France
Investigateur principal : Dr Samuel Abbou
Institutions participantes et pays : Autriche, Allemagne, Danemark, Espagne, France, Italie, Pays-Bas et Royaume-Uni
2. EurHoly, guérir plus et mieux les lymphomes hodgkiniens pédiatriques
Le lymphome hodgkinien classique représente la première cause de cancer à l’adolescence, avec près de 120 cas de lymphome hodgkinien classique pédiatrique en France et 160 cas en Allemagne chaque année. Parmi les patients, 10 à 15% des enfants et des adolescents diagnostiqués sont victimes de rechute et la stratification du risque est la pierre angulaire du traitement de ce cancer.
L’objectif de ce projet est de développer un marqueur biologique (ctDNA) qui pourrait affiner la stratification initiale du risque, améliorer l’évaluation de la maladie pendant et après le traitement et faciliter la détection des rechutes. De plus, ce biomarqueur pourrait également permettre de réduire la toxicité du traitement en limitant l’indication de la radiothérapie aux patients à très haut risque de rechute. D’autre part, l’identification des patients avec de très bons résultats pourrait conduire à une approche de désescalade et ainsi réduire la morbidité à long terme due à la chimiothérapie..
Durée du projet : 3 ans
Domaine : Projet translationnel sur le Lymphome hodgkinien
Institution principale : Hôpital Armand Trousseau, Université de la Sorbonne, France
Investigateur principal : Dr Mathieu Simonin
Institutions participantes et pays : Centre de Lutte contre le Cancer Henri Becquerel, France / Justus Liebieg-Université de Giessen, Allemagne
3. MedulloDrugs, trouver des nouveaux traitements dans les médulloblastomes
Les cancers du cerveau, y compris le médulloblastome, sont toujours considérés comme la principale cause de décès chez les enfants et adolescents vivants avec un cancer. En effet, depuis de nombreuses années, peu de progrès ont été réalisés pour concevoir de nouveaux traitements concernant ces types de cancers. L’une des raisons est le manque de nouveaux modèles pour les tester.
Ce projet vise à répondre à cela en tirant parti des organoïdes cérébraux. En effet, ce modèle permet de créer des versions miniaturisées d’un tissu ou d’un organe touché par un cancer, de le dupliquer et de tester de nombreuses combinaisons de médicaments. L’objectif est d’étudier ce modèle sur le médulloblastome et a terme de cibler les médicaments efficaces, de trouver les bonnes combinaisons et d’en faire de potentiels traitements.
Durée du projet : 3 ans
Domaine : Projet translationnel sur le Medulloblastome
Institution principale : University de Trente, Italie
Investigateur principal : Dr Luca Tiberi
Institutions participantes et pays : Institut Curie, France
4. EpiTarget-kids, développer des thérapies ciblées pour les gliomes infiltrants du tronc cérébral (GITC)
Les gliomes de haut grade sont des tumeurs malignes du système nerveux central qui représentent environ 40 % des cancers pédiatriques du cerveau et touchent environ près de 400 nouveaux enfants en Europe chaque année. Les gliomes de haut grade restent l’un des plus grands défis thérapeutiques en oncologie pédiatrique. Parmi ces cancers, les gliomes infiltrants du tronc cérébral représentent la principale cause de décès liés aux tumeurs cérébrales chez l’enfant.
Malgré les nombreux efforts déployés dans les essais cliniques, les traitements ciblant les gliomes infiltrants du tronc cérébral ont une faible efficacité, et conduisent à une survie globale de 9 à 11 mois après le diagnostic. L’un des obstacles à l’identification de meilleurs traitements est le manque de modèles in vitro appropriés pour les tumeurs pédiatriques. Ce projet vise à résoudre ce problème en utilisant des « mini-cerveaux », cultivés in vitro, pour révéler les vulnérabilités des gliomes infiltrants du tronc cérébral afin de développer de nouveaux traitements.
À terme, cette étude doit permettre de jeter les bases du développement de stratégies thérapeutiques nouvelles et personnalisées pour les gliomes infiltrants du tronc cérébral.
Durée du projet : 2 ans
Domaine : Projet translationnel sur les Gliomes Pontins Intrinsèques Diffus
Institution principale : Agence Internationale de la Rercheche sur le Cancer (IARC), France
Investigateur principal : Dr Rita Khoueiry
Institutions participantes et pays : Centre de Recherche sur le Cancer de Lyon, France / Université de Strasbourg, France / Centre de Recherche pour la médecine moléculaire de l’Académie Autrichienne des Sciences, Autriche
5. ATG4TALL, une plateforme de tests pour améliorer le taux de guérison des patients atteints d’une leucémie aiguë lymphoblastique (LAL-T)
La leucémie aiguë lymphoblastique est le cancer le plus courant chez les enfants, et peut affecter les lymphocytes B ou T. Lorsque la leucémie à Lymphocytes T ne répond pas bien au traitement initial (maladie dite résistante) ou en cas de récidive (rechutes), seuls trois enfants sur dix guériront.
Ce projet, en lien avec l’essai clinique ALLTOGETHER (14 pays), vise à développer une plateforme de test permettant de déterminer les combinaisons de médicaments, déjà existants, qui vont traiter efficacement les cellules leucémiques.
Durée du projet : 2 ans
Domaine : Projet translationnel sur la Leucémie lymphoblastique aiguë de type T
Institution principale : Princess Maxima Center for Pediatric Oncology, The Netherlands
Investigateur principal : Dr Frank van Leeuwen
Institutions participantes et pays : University of Glasgow, UK / University of Newcastle, UK / UCL Cancer Institute, UK / University Medical Center Hamburg Eppendorf, Germany / University of Lisbon, Portugal / APHP, France / University College Dublin, Ireland / Umea University, Sweden / University of Ghent, Belgium
6. ENCOURAGER, guérir plus les tumeurs cérébrales et gliomes
Chaque année, plus de 2500 enfants et adolescents en Europe sont diagnostiqués avec des tumeurs cérébrales, la principale cause de décès pédiatrique dû au cancer dans tous les pays européens. Malgré les progrès réalisés dans la détection et le traitement des tumeurs, environ 1 enfant et adolescent sur 4 atteints d’une tumeur cérébrale succombe à sa maladie, en raison d’une récidive et d’un échec du traitement.
Malgré les progrès pour réaliser des traitements personnalisés, de nombreux défis demeurent, en particulier lorsqu’un traitement échoue en raison d’une résistance aux médicaments administrés. Ce projet vise à relever certains de ces défis, et notamment :
- empêcher le développement d’une résistance aux médicaments pendant le traitement
- repousser les limites des approches de profilage tumoral afin de mieux détecter les cellules résistantes.
En augmentant l’efficacité des thérapies et la prévention de l’échec du traitement, nous améliorerons le pronostic des enfants atteints de cancers à haut risque.
Durée du projet : 2 ans
Domaine : Projet translationnel sur les Tumeurs cérébrales & gliomes
Institution principale : University Children’s Hospital Zürich, Switzerland
Investigateur principal : Dr Ana Guerreiro Stücklin
Institutions participantes et pays : Institut Curie, France
7. Skeletal late effects, comprendre et prévenir les effets secondaires de la radiothérapie
La radiothérapie est l’un des traitements majeurs pour les cancers pédiatriques mais a des effets secondaires, notamment des effets squelettiques tardifs. Ces effets secondaires sont assez importants et les dommages causés par les radiations sur le squelette en croissance ne sont toujours pas compris. Ce projet vise à comprendre les conséquences osseuses de la radiothérapie et à tester de nouvelles stratégies pour les prévenir.
Durée du projet : 2 ans
Domaine : Projet translationnel sur les effets secondaires de la radiothérapie
Institution principale : Karolinska Institut, Suède
Investigateur principal : Dr Phillip Newton
Institutions participantes et pays : Lausanne University Hospital, Suisse
8. REMODELING, rendre efficace l’immunothérapie pour les tumeurs cérébrales
À l’heure actuelle, il n’existe aucun traitement curatif pour les 800 enfants diagnostiqués, chaque année, avec un gliome de haut grade en Europe. 70 à 80 % ont un gliome diffus de la ligne médiane (GDM) incurable, également appelé GITC lorsqu’il est situé dans le tronc cérébral. Indépendamment de la thérapie extensive (chirurgie associée, si possible, à la radiothérapie et la chimiothérapie), la survie des patients est très basse, puisque le taux de survie à 5 ans est seulement compris entre 2 et 5 %. Des progrès considérables ont été faits pour améliorer la survie d’autres patients pédiatriques atteints de cancer. Par exemple, l’immunothérapie a révolutionné les stratégies thérapeutiques, mais reste inefficace contre les gliomes de haut grade, en grande partie en raison de la barrière hémato-encéphalique qui limite grandement le passage de médicaments dans le cerveau.
Ce projet vise à amener des solutions au sein des tumeurs cérébrales pour réactiver les cellules immunitaires qui y sont déjà présentes. Des ondes ultrasonores non invasives seront utilisées afin d’ouvrir la barrière hémato-encéphalique. Ce projet conduira à de nouvelles découvertes qui permettront de mieux comprendre comment modifier le système immunitaire à l’intérieur des tumeurs cérébrales chez les enfants, avec l’ambition de découvrir des immunothérapies plus efficaces, qui peuvent bénéficier à la fois aux enfants et aux adultes atteints de ce type de cancer, non seulement en Europe, mais dans le monde entier.
Durée du projet : 2 ans
Domaine : Projet translationnel sur les gliomes diffus de la ligne médiane
Institution principale : Princess Maxima Center for Pediatric Oncology, Pay-Bas
Investigateur principal : Dr John Bianco
Institutions participantes et pays : Leiden University Medical Center, Pays-Bas
9. BioESMART, confirmer le potentiel d’un traitement pour les sarcomes d’Ewing
Le sarcome d’Ewing est une maladie complexe, sans réelle amélioration du pourcentage de guérison depuis 2013 (73%). Un traitement ciblant spécifiquement l’IGF-1R (récepteur de l’IGF-1, un facteur de croissance) des sarcomes d’Ewing a montré des résultats prometteurs dans le passé, mais n’ont pas été confirmés par la suite.
Ce projet visera à mieux comprendre le rôle de l’IGF-1R dans la carcinogenèse de cette maladie et déterminera la population spécifique de patients qui répondrait à un nouveau traitement ciblé. L’ensemble des résultats pourrait permettre d’améliorer la sélection des patients dans les prochains essais cliniques avec une thérapie ciblée contre l’IGF-1R et d’ajouter une étape importante dans le développement d’un traitement.
Durée du projet : 2 ans
Domaine : Projet translationnel sur le Sarcome d’Ewing
Institution principale : CHU Bordeaux, France
Investigateur principal : Dr Jordane Chaix
Institutions participantes et pays : Institut Gustave Roussy, France / Institut Curie, France / University Children’s Hospital Zürich, Suisse